Epitalon / references
Epitalon References: The Cited Literature
Every Epitalon claim on this site maps to a numbered source below, with its PMID and DOI for verification.
About these Epitalon references
The Epitalon references below are the primary sources cited across this site. Most are indexed in PubMed; each entry carries its PMID and, where one is assigned, its DOI. The list reflects the state of the record: a concentration of foundational work from the Khavinson group at the St. Petersburg Institute, a small body of observational human data, and the independent 2024-2025 studies that have begun to engage the core telomere claim. Sources are listed in the numbered order they are referenced on the site.
- Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. ↗
- Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. ↗
- Anisimov VN, Khavinson VKh, Provinciali M, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. ↗
- Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. ↗
- Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties (safety and characterization limits). Int J Mol Sci. 2025;26(6):2691. ↗
- Khavinson VKh, Linkova NS, Kvetnoy IM, et al. Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. Bull Exp Biol Med. 2012;153(2):255-258. ↗
- Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cells. Bull Exp Biol Med. 2004;137(5):503-506. ↗
- Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178. ↗
- Khavinson VKh, Razumovsky M, et al. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuro Endocrinol Lett. 2002;23(4):365-368. ↗
- Kossoy G, Anisimov VN, et al. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. ↗
- Anisimov VN, et al. Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM). Vopr Onkol. 2005;51(1):93-98. ↗
- Kossoy G, Anisimov VN, Ben-Hur H, et al. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett. 2002;183(1):1-4. ↗
- Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions. Eksp Klin Farmakol. 2006;69(4):13-15. ↗
- Anisimov VN, Khavinson VKh, Provinciali M, et al. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2002;101(1):7-10. ↗
- Korkushko OV, Shatilo VB, Khavinson VKh, et al. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med. 2006;142(1):73-77. ↗